Bypassing clinical trials of COVID-19 vaccine 'catastrophic,' says editorialhttp://global.chinadaily.com.cn/a/202005/23/WS5ec88c5ca310a8b241157ca4.html
Bypassing clinical trials of a potential vaccine for #SARS-CoV-2
, the virus causing #COVID-19
, would be "catastrophic," said an editorial published on #Science
Advances on Friday.
It is "vital to take time" to ensure any vaccine candidate's safety and investigate potential adverse effects, said the editorial by Douglas Green, deputy editor of the multidisciplinary scientific journal.
A vaccine able to trigger strong neutralizing antibody responses in #clinical
tests will still not be ready for widespread implementation without comprehensive safety tests, wrote Green, who is also an expert on #immunology
Vaccines must be examined for causing an effect known as antibody-dependent enhancement, whereby #vaccine-induced
that bind to the #virus
also attach to the body's #cells
, facilitating #infection
of these cells -- a concerning phenomenon that has been observed in vaccines against #dengue
, and #feline
, said the editorial.
Ethical accelerated testing on humans "should not be ruled out completely," but extreme risks must be weighed against potential benefits, it said.
There are currently 95 vaccines under development against SARS-CoV-2, with most expected to clear phase one, and two already moving into phase two trials, it added.
WASHINGTON - Bypassing clinical trials of a potential vaccine for SARS-CoV-2, the virus causing COVID-19, would be "catastrophic," said an editorial published on Science Advances on Friday.global.chinadaily.com.cn