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Recovered COVID-19 patients test positive but not infectious, data finds | Ars Technica

People who recover from COVID-19 but test positive for the virus again days or weeks later are not shedding viral particles and are not infectious, according to data released Tuesday by the Korea Centers for Disease Control and Prevention.
#science #medicine #health #Covid-19 #CoronaVirus
 

Recovered COVID-19 patients test positive but not infectious, data finds | Ars Technica

People who recover from COVID-19 but test positive for the virus again days or weeks later are not shedding viral particles and are not infectious, according to data released Tuesday by the Korea Centers for Disease Control and Prevention.
#science #medicine #health #Covid-19 #CoronaVirus
 

Coronavirus: Scientists hail 'groundbreaking' discovery of antibody which prevents infection | Science & Tech News | Sky News

Scientists have discovered an antibody which prevents the coronavirus from infecting human cells in "groundbreaking research" which could lead to the development of new treatments.

Building on research into the SARS coronavirus, scientists from Utrecht University in the Netherlands, as well as the Erasmus Medical Centre and the company Harbour BioMed (HBM), have identified a potential method of neutralising COVID-19.

They discovered that an antibody which prevents the SARS virus from infecting human cells could also block the novel coronavirus from infecting human cells too, according a peer reviewed study published on Monday in the journal Nature Communications.
#science #medicine #health #Covid-19 #CoronaVirus
 

Coronavirus: Scientists hail 'groundbreaking' discovery of antibody which prevents infection | Science & Tech News | Sky News

Scientists have discovered an antibody which prevents the coronavirus from infecting human cells in "groundbreaking research" which could lead to the development of new treatments.

Building on research into the SARS coronavirus, scientists from Utrecht University in the Netherlands, as well as the Erasmus Medical Centre and the company Harbour BioMed (HBM), have identified a potential method of neutralising COVID-19.

They discovered that an antibody which prevents the SARS virus from infecting human cells could also block the novel coronavirus from infecting human cells too, according a peer reviewed study published on Monday in the journal Nature Communications.
#science #medicine #health #Covid-19 #CoronaVirus
 

Coronavirus: Hospital cuts COVID-19 death rates with 'black boxes' for sleep disorder | UK News | Sky News

Medics fighting COVID-19 in a hospital in Cheshire seem to have cut mortality rates and improved the chances of a quick recovery from the virus by adapting breathing machines normally used for a sleeping disorder.
#science #medicine #health #Covid-19 #CoronaVirus
 

Coronavirus: Hospital cuts COVID-19 death rates with 'black boxes' for sleep disorder | UK News | Sky News

Medics fighting COVID-19 in a hospital in Cheshire seem to have cut mortality rates and improved the chances of a quick recovery from the virus by adapting breathing machines normally used for a sleeping disorder.
#science #medicine #health #Covid-19 #CoronaVirus
 

Coronavirus In The Pipeline

Research chemist Derek Lowe weighs in on the real-world scientific meaning and medical relevance of some of the studies on chloroquine and hydrochloroquine


https://blogs.sciencemag.org/pipeline/archives/2020/03/31/comparing-chloroquine-trials

This first article discusses a new, properly controlled study out of Wuhan, China.
This is actually the first controlled study to show any benefit for chloroquine or hydroxychloroquine therapy against the coronavirus – it may sound odd to say that, but all the positive reports we have had up to now are anecdotal reports and open-label studies without control groups.

[...]
You could argue that overall we’re seeing either no benefit or some benefit here, which is good. As for adverse events, neither trial reported anything serious, But both of them excluded patients with any sort of cardiac arrhythmias, a wise precaution since one of the most acute worries with high doses of hydroxychloroquine is QT-interval prolongation, and you don’t want to do that to anyone with any underlying problems. So as long as such patients are excluded, for now hydroxychloroquine is in the “might do nothing, might do some good” category, which under the current conditions seems sufficient for treating patients, pending further data. You will notice that we are not exactly in the “total cure” category that the Marseilles group has been putting itself in, but frankly, these results from China are more like what I expect from the clinic (at best!) when using a repurposed drug against such a pathogen.
Notice the portion I have highlighted there. Hydroxychloroquine "might do some good" in patients lacking any pre-existing heart conditions or predisposition to such. And this is the most positive scientifically reliable result published to date. (And we'll come back to that "patients with existing problems" detail later.)
So why aren't the "100% miracle cure!" studies reliable? Well, let's go on to the other article, published two days earlyer, and talking about the French Dr. Raoult, his "studies", and his scientific reputation. Which isn't good:

https://blogs.sciencemag.org/pipeline/archives/2020/03/29/more-on-cloroquine-azithromycin-and-on-dr-raoult
Patients were give a CT scan shortly after admission to look for pneumonia – the body of the article says that patients “systematically underwent” this test, but the data tables show that 20% of the subjects were not evaluated. Of those who were, 54% had radiologic pneumonia signs. Nasal swabs were taken daily (“with some exceptions”) and analyzed for viral RNA via RT-PCR. Cultures, meanwhile “were attempted in a random selection of patients”.
In short, completely hit-and-miss. Treatments were not consistent from one patient to the next. Patients were not uniformly evaluated. Dosages of additional treatments on top of what was being studied were not recorded nor taken into effect. There is no control group. And things only get worse from there on.
That takes us to Dr. Raoul’s other published work. For extended comment on this I refer the reader to this post by Leonid Schneider at For Better Science. To summarize, there are a number of papers published from his lab over the years that have some of the better-known publication sins: duplication of photomicrographs, photoshopped blots. One of these in 2006 was egregious enough that Raoult and several of his co-authors were banned from publishing in any ASM (American Society for Microbiology) journals for a year.
And this is only one of many complaints regarding Dr. Raoult's methodology, objectivity, and veracity.
On to Derek's April 6 update.

https://blogs.sciencemag.org/pipeline/archives/2020/04/06/hydroxychloroquine-update-for-april-6

I'm going to call out a couple of ;points from this one and leave the rest to you:
  • A small study from a team at the University of Paris and Saint-Louis Hospital in Paris, admittedly with a "tough population" (which is to say, one generally matching exactly the people already known to be at greatest risk from Covid-19, "provides no evidence to show that the HCQ/AZ combination had any benefit at all."
  • Lowe observes that the very reason hydroxychloroquine is of use in the treatment of lupus and rheumatoid arthritis, both of them auto-immune disorders, is because it reduces activity of the innate immune system. This seems to be exactly the last thing you want to do when fighting a global pandemic.
  • Lowe also points out a preprint study in mice which has found an adverse interaction between hydroxychloroquine and metformin (a drug used to help control and treat diabetes), which has a 30% mortality rate in mice. If — and it is by no means certain — this effect carries over to humans as well, that means that hydroxychloroquine treatment could be fatal fpr diabetic patients who take metformin.
  • Lastly, I call out Lowe's mention of a study from Denmark with re-analyzes Dr. Raoult's original Marseilles study and finds it to have, overall, only anecdotally significant results. In other words, it was scientifically irresponsible to publish such a weak result in the first place — let alone to trumpet it as a miracle cure. Dr. Raoult's results look good at first — as long as you ignore the patients whose condition deteriorated. And that's like saying that it's perfectly safe to jump off a two-storey building, you won't break your legs, as long as you ignore the people who break their legs. Or Russian roulette is completely safe as long as you survey only people who survive playing it.
#science #medicine #coronaviros #hydroxychloroquine
 

Coronavirus In The Pipeline

Research chemist Derek Lowe weighs in on the real-world scientific meaning and medical relevance of some of the studies on chloroquine and hydrochloroquine


https://blogs.sciencemag.org/pipeline/archives/2020/03/31/comparing-chloroquine-trials

This first article discusses a new, properly controlled study out of Wuhan, China.
This is actually the first controlled study to show any benefit for chloroquine or hydroxychloroquine therapy against the coronavirus – it may sound odd to say that, but all the positive reports we have had up to now are anecdotal reports and open-label studies without control groups.

[...]
You could argue that overall we’re seeing either no benefit or some benefit here, which is good. As for adverse events, neither trial reported anything serious, But both of them excluded patients with any sort of cardiac arrhythmias, a wise precaution since one of the most acute worries with high doses of hydroxychloroquine is QT-interval prolongation, and you don’t want to do that to anyone with any underlying problems. So as long as such patients are excluded, for now hydroxychloroquine is in the “might do nothing, might do some good” category, which under the current conditions seems sufficient for treating patients, pending further data. You will notice that we are not exactly in the “total cure” category that the Marseilles group has been putting itself in, but frankly, these results from China are more like what I expect from the clinic (at best!) when using a repurposed drug against such a pathogen.
Notice the portion I have highlighted there. Hydroxychloroquine "might do some good" in patients lacking any pre-existing heart conditions or predisposition to such. And this is the most positive scientifically reliable result published to date. (And we'll come back to that "patients with existing problems" detail later.)
So why aren't the "100% miracle cure!" studies reliable? Well, let's go on to the other article, published two days earlyer, and talking about the French Dr. Raoult, his "studies", and his scientific reputation. Which isn't good:

https://blogs.sciencemag.org/pipeline/archives/2020/03/29/more-on-cloroquine-azithromycin-and-on-dr-raoult
Patients were give a CT scan shortly after admission to look for pneumonia – the body of the article says that patients “systematically underwent” this test, but the data tables show that 20% of the subjects were not evaluated. Of those who were, 54% had radiologic pneumonia signs. Nasal swabs were taken daily (“with some exceptions”) and analyzed for viral RNA via RT-PCR. Cultures, meanwhile “were attempted in a random selection of patients”.
In short, completely hit-and-miss. Treatments were not consistent from one patient to the next. Patients were not uniformly evaluated. Dosages of additional treatments on top of what was being studied were not recorded nor taken into effect. There is no control group. And things only get worse from there on.
That takes us to Dr. Raoul’s other published work. For extended comment on this I refer the reader to this post by Leonid Schneider at For Better Science. To summarize, there are a number of papers published from his lab over the years that have some of the better-known publication sins: duplication of photomicrographs, photoshopped blots. One of these in 2006 was egregious enough that Raoult and several of his co-authors were banned from publishing in any ASM (American Society for Microbiology) journals for a year.
And this is only one of many complaints regarding Dr. Raoult's methodology, objectivity, and veracity.
On to Derek's April 6 update.

https://blogs.sciencemag.org/pipeline/archives/2020/04/06/hydroxychloroquine-update-for-april-6

I'm going to call out a couple of ;points from this one and leave the rest to you:
  • A small study from a team at the University of Paris and Saint-Louis Hospital in Paris, admittedly with a "tough population" (which is to say, one generally matching exactly the people already known to be at greatest risk from Covid-19, "provides no evidence to show that the HCQ/AZ combination had any benefit at all."
  • Lowe observes that the very reason hydroxychloroquine is of use in the treatment of lupus and rheumatoid arthritis, both of them auto-immune disorders, is because it reduces activity of the innate immune system. This seems to be exactly the last thing you want to do when fighting a global pandemic.
  • Lowe also points out a preprint study in mice which has found an adverse interaction between hydroxychloroquine and metformin (a drug used to help control and treat diabetes), which has a 30% mortality rate in mice. If — and it is by no means certain — this effect carries over to humans as well, that means that hydroxychloroquine treatment could be fatal fpr diabetic patients who take metformin.
  • Lastly, I call out Lowe's mention of a study from Denmark with re-analyzes Dr. Raoult's original Marseilles study and finds it to have, overall, only anecdotally significant results. In other words, it was scientifically irresponsible to publish such a weak result in the first place — let alone to trumpet it as a miracle cure. Dr. Raoult's results look good at first — as long as you ignore the patients whose condition deteriorated. And that's like saying that it's perfectly safe to jump off a two-storey building, you won't break your legs, as long as you ignore the people who break their legs. Or Russian roulette is completely safe as long as you survey only people who survive playing it.
#science #medicine #coronaviros #hydroxychloroquine
 

Disabled people cut off from vital supplies due to panic buying | World news | The Guardian

Disabled people are being left cut off from vital supplies due to the coronavirus pandemic, as charities warn of a rising number of calls from worried individuals who are struggling.
#science #medicine #health #Covid-19 #CoronaVirus #disability
 

Disabled people cut off from vital supplies due to panic buying | World news | The Guardian

Disabled people are being left cut off from vital supplies due to the coronavirus pandemic, as charities warn of a rising number of calls from worried individuals who are struggling.
#science #medicine #health #Covid-19 #CoronaVirus #disability
 

Japanese flu drug 'clearly effective' in treating coronavirus, says China | World news | The Guardian

Medical authorities in China have said a drug used in Japan to treat new strains of influenza appeared to be effective in coronavirus patients, Japanese media said on Wednesday.
#science #medicine #health #Covid-19 #CoronaVirus
 

Japanese flu drug 'clearly effective' in treating coronavirus, says China | World news | The Guardian

Medical authorities in China have said a drug used in Japan to treat new strains of influenza appeared to be effective in coronavirus patients, Japanese media said on Wednesday.
#science #medicine #health #Covid-19 #CoronaVirus
 
Man with 5.5-inch horn growing on his back slipped “through the net,” docs say | Ars Technica

I'm tagging this as #nsfw cause the article includes pictures

#medicine #health #science
 

Tag 2 #36C3: #Vortragsempfehlugen für Sozial- & Gemeinwesenarbeitende


Die Livestreams findet ihr hier nach Räumen sortiert: https://streaming.media.ccc.de/36c3/

Sa, 28.12.2019#digitaleSoA #servicepost #livestream #ccc #talks #aboutsocial
 

Tag 2 #36C3: #Vortragsempfehlugen für Sozial- & Gemeinwesenarbeitende


Die Livestreams findet ihr hier nach Räumen sortiert: https://streaming.media.ccc.de/36c3/

Sa, 28.12.2019#digitaleSoA #servicepost #livestream #ccc #talks #aboutsocial
 
#science #medicine
 
#science #medicine
 
Medical research ranked higher by people receiving health-related news while they wait

This is interesting and a good idea.
#science #research #medicine
 
Psychedelic Medicine Is Coming. The Law Isn’t Ready
A surprising resurgence of psychedelic research has produced its first FDA-approved treatment, with more likely on the way

In March, the Food and Drug Administration approved esketamine, a drug that produces psychedelic effects, to treat depression—the first psychedelic ever to clear that bar. Meanwhile the FDA has granted "breakthrough therapy" status—a designation that enables fast-tracked research—to study MDMA (also called "ecstasy") as a treatment for post-traumatic stress disorder and psilocybin as a treatment for major depression.

#medicine #drugs #psychedelics
 
Psychedelic Medicine Is Coming. The Law Isn’t Ready
A surprising resurgence of psychedelic research has produced its first FDA-approved treatment, with more likely on the way

In March, the Food and Drug Administration approved esketamine, a drug that produces psychedelic effects, to treat depression—the first psychedelic ever to clear that bar. Meanwhile the FDA has granted "breakthrough therapy" status—a designation that enables fast-tracked research—to study MDMA (also called "ecstasy") as a treatment for post-traumatic stress disorder and psilocybin as a treatment for major depression.

#medicine #drugs #psychedelics
 
The UK is well prepared for a no deal Brexit. In the case of medicine, food, fuel or water shortages the stoic Englanders will just be optimistic, develop a can do spirit and think of Dunkirk. Something like that.
UK weather: Overheating crowds storm lido and fights break out in queue as temperatures soar
#Brexit #UK #EU #politics #nodeal #shortages #preparedness #food #medicine #BorisJohnson
 

#Science #Methodology #CultureWars | To Fix the #Social Sciences, Look to the “Dark Ages” of #Medicine | The MIT Press Reader http://bit.ly/322CXd6

To Fix the Social Sciences, Look to the “Dark Ages” of Medicine

The MIT Press Reader: To Fix the Social Sciences, Look to the “Dark Ages” of Medicine (Anar Badalov)

 

#Science #Methodology #CultureWars | To Fix the #Social Sciences, Look to the “Dark Ages” of #Medicine | The MIT Press Reader http://bit.ly/322CXd6

To Fix the Social Sciences, Look to the “Dark Ages” of Medicine

The MIT Press Reader: To Fix the Social Sciences, Look to the “Dark Ages” of Medicine (Anar Badalov)

 
#medicine #ineffective #medical #reversal

Study Finds Nearly 400 Medical Devices, Procedures And Practices That Are Ineffective



When a medical treatment, device or procedure is no better than previous or lesser alternatives, it's deemed a 'medical reversal'. These discredited practices are a major barrier to better and cheaper healthcare, but actually identifying them is surprisingly difficult and rarely done.

A recent study, designed to create a more comprehensive list, has unearthed nearly 400 established treatments, devices and procedures that fit this bill.

"We hope our broad results may serve as a starting point for researchers, policy makers and payers who wish to have a list of practices that likely offer no net benefit to use in future work," says hematologist-oncologist Vinay Prasad from Oregon Health & Science University (OHSU), who helped coin the term 'medical reversal'.

The findings are based on more than 15 years of randomised controlled trials, a type of research that aims to reduce bias when testing new treatments. Across 3,000 articles in three leading medical journals from the UK and the US, the authors found 396 reversals.
 
#medicine #ineffective #medical #reversal

Study Finds Nearly 400 Medical Devices, Procedures And Practices That Are Ineffective



When a medical treatment, device or procedure is no better than previous or lesser alternatives, it's deemed a 'medical reversal'. These discredited practices are a major barrier to better and cheaper healthcare, but actually identifying them is surprisingly difficult and rarely done.

A recent study, designed to create a more comprehensive list, has unearthed nearly 400 established treatments, devices and procedures that fit this bill.

"We hope our broad results may serve as a starting point for researchers, policy makers and payers who wish to have a list of practices that likely offer no net benefit to use in future work," says hematologist-oncologist Vinay Prasad from Oregon Health & Science University (OHSU), who helped coin the term 'medical reversal'.

The findings are based on more than 15 years of randomised controlled trials, a type of research that aims to reduce bias when testing new treatments. Across 3,000 articles in three leading medical journals from the UK and the US, the authors found 396 reversals.
 
Bild/Foto

DYSMENORRHEA


dys·men·or·rhe·a
noun: painful menstruation, typically involving abdominal cramps

This condition is very common. The pathomechanism (cause) has two main components: abnormal blood flow patterns and hormone system dysregulation. When blood flow is poor, the uterus will cramp as it struggles to shed the lining. The quality of blood will be clumpy and dark showing a pattern of blood stagnation.

Although each patient is unique and requires an individualized approach, here is a base prescription I have used with great outcomes:
- Paeoniae Radix alba
- Atractylodis macrocephalae Rhizoma
- Chuanxiong Rhizoma
- Angelicae sinensis Radix
- Poria
- Alismatis Rhizoma

Note: the primary function of this prescription is to nourish and move the uterine blood.
#medicine #herbalism
 
Bild/Foto

DYSMENORRHEA


dys·men·or·rhe·a
noun: painful menstruation, typically involving abdominal cramps

This condition is very common. The pathomechanism (cause) has two main components: abnormal blood flow patterns and hormone system dysregulation. When blood flow is poor, the uterus will cramp as it struggles to shed the lining. The quality of blood will be clumpy and dark showing a pattern of blood stagnation.

Although each patient is unique and requires an individualized approach, here is a base prescription I have used with great outcomes:
- Paeoniae Radix alba
- Atractylodis macrocephalae Rhizoma
- Chuanxiong Rhizoma
- Angelicae sinensis Radix
- Poria
- Alismatis Rhizoma

Note: the primary function of this prescription is to nourish and move the uterine blood.
#medicine #herbalism
 
Bild/Foto

Remember to have a good breakfast comrades


I post pictures / meme every day about anarchy and other cool stuff.
Feel free to download and share them ! :)

#shitposting #anarchist meme for cool people
#anarchism #revolution #anonymous #food
#nutrition #health #food #medicine "breakfast
#drugs #unhealthy #habits #food #lifestyle #tip #tips
 
Swiss Medical Weekly - A curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager

That's why #homeopathy is dangerous.
#science #medicine
 

Why homeopathy is successful despite scientific contradiction


He believed that if medicine was to move from sequential delusions towards effective truth, then we should not just look at why each successive medical theory was wrong, but to come up with general reasons why doctors and their patients continually make mistakes about what is effective and what is not.

People inevitably seek treatments when symptoms are at their worst. It is equally inevitable that we will subsequently have better days, even if our chosen treatment was ineffective. Jumping to conclusions, based on simple experiences of treatments, can quickly lead us to error. This point may appear trivial, and yet it is the foundation for belief in all superstitious and pseudo-scientific treatments.

Such a notion of dilution resulting in larger effects is counter to our everyday understanding of the world. You do not make coffee stronger by diluting it. You do not get drunk on shandy. Because all homeopathic remedies are essentially identically inert pills, homeopaths are free to make remedies from any and all substances no matter how poisonous, harmless or daft. On Ainsworths sales site, you can buy remedies made from Asbestos, Positronium, Tyrannosaurus Rex, Brillo Pad and Twiglets. You are not told about such remedies on public blog posts because you are not in the cult and you are still freely thinking.

Sure, why not try some asbestos pills, they will surely cure you soon. Or vanish you from the earth, which may be called a cure as well, depending on who you ask.
#Science #Homeopathy #SnakeOilVendors #Quacks #Evolution #Devolution #Degeneracy #Health #Healthcare #Medicine #Pharmaceuticals #Natural #Confusion #StateOfConfusion
Why is Homeopathy Successful?
 

Why homeopathy is successful despite scientific contradiction


He believed that if medicine was to move from sequential delusions towards effective truth, then we should not just look at why each successive medical theory was wrong, but to come up with general reasons why doctors and their patients continually make mistakes about what is effective and what is not.

People inevitably seek treatments when symptoms are at their worst. It is equally inevitable that we will subsequently have better days, even if our chosen treatment was ineffective. Jumping to conclusions, based on simple experiences of treatments, can quickly lead us to error. This point may appear trivial, and yet it is the foundation for belief in all superstitious and pseudo-scientific treatments.

Such a notion of dilution resulting in larger effects is counter to our everyday understanding of the world. You do not make coffee stronger by diluting it. You do not get drunk on shandy. Because all homeopathic remedies are essentially identically inert pills, homeopaths are free to make remedies from any and all substances no matter how poisonous, harmless or daft. On Ainsworths sales site, you can buy remedies made from Asbestos, Positronium, Tyrannosaurus Rex, Brillo Pad and Twiglets. You are not told about such remedies on public blog posts because you are not in the cult and you are still freely thinking.

Sure, why not try some asbestos pills, they will surely cure you soon. Or vanish you from the earth, which may be called a cure as well, depending on who you ask.
#Science #Homeopathy #SnakeOilVendors #Quacks #Evolution #Devolution #Degeneracy #Health #Healthcare #Medicine #Pharmaceuticals #Natural #Confusion #StateOfConfusion
Why is Homeopathy Successful?
 
Bild/Foto

Blue Magnetic Putty Swallowing A Metal Sphere


Also, this looks just like phagocytosis (when the immune system engulfs a pathogen).
#medicine #science
 
Bild/Foto

Blue Magnetic Putty Swallowing A Metal Sphere


Also, this looks just like phagocytosis (when the immune system engulfs a pathogen).
#medicine #science
 
It's an old (for the internet standard) article, but I don't recall having seen this in the news before, and it actually was on Slashdot a few days ago.
…and yes, it's as nasty as it looks.
#cure #medicine #GoldmanSachs #business #sustainable

Goldman asks: 'Is curing patients a sustainable business model?'


Bild/Foto
"GILD is a case in point, where the success of its hepatitis C franchise has gradually exhausted the available pool of treatable patients," the analyst wrote. "In the case of infectious diseases such as hepatitis C, curing existing patients also decreases the number of carriers able to transmit the virus to new patients, thus the incident pool also declines … Where an incident pool remains stable (eg, in cancer) the potential for a cure poses less risk to the sustainability of a franchise."
 
It's an old (for the internet standard) article, but I don't recall having seen this in the news before, and it actually was on Slashdot a few days ago.
…and yes, it's as nasty as it looks.
#cure #medicine #GoldmanSachs #business #sustainable

Goldman asks: 'Is curing patients a sustainable business model?'


Bild/Foto
"GILD is a case in point, where the success of its hepatitis C franchise has gradually exhausted the available pool of treatable patients," the analyst wrote. "In the case of infectious diseases such as hepatitis C, curing existing patients also decreases the number of carriers able to transmit the virus to new patients, thus the incident pool also declines … Where an incident pool remains stable (eg, in cancer) the potential for a cure poses less risk to the sustainability of a franchise."
 
Bild/Foto
The average human brain has about 100 billion neurons (or nerve cells) and many more neuroglia (or glial cells) which serve to support and protect the neurons.
#medicine #science
 
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