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Bypassing clinical trials of COVID-19 vaccine 'catastrophic,' says editorial

http://global.chinadaily.com.cn/a/202005/23/WS5ec88c5ca310a8b241157ca4.html

Bypassing clinical trials of a potential vaccine for #SARS-CoV-2, the virus causing #COVID-19, would be "catastrophic," said an editorial published on #Science Advances on Friday.

It is "vital to take time" to ensure any vaccine candidate's safety and investigate potential adverse effects, said the editorial by Douglas Green, deputy editor of the multidisciplinary scientific journal.

A vaccine able to trigger strong neutralizing antibody responses in #clinical tests will still not be ready for widespread implementation without comprehensive safety tests, wrote Green, who is also an expert on #immunology.

Vaccines must be examined for causing an effect known as antibody-dependent enhancement, whereby #vaccine-induced #antibodies that bind to the #virus also attach to the body's #cells, facilitating #infection of these cells -- a concerning phenomenon that has been observed in vaccines against #dengue, #Ebola, #HIV, and #feline #coronavirus, said the editorial.

Ethical accelerated testing on humans "should not be ruled out completely," but extreme risks must be weighed against potential benefits, it said.

There are currently 95 vaccines under development against SARS-CoV-2, with most expected to clear phase one, and two already moving into phase two trials, it added.
 
Bypassing clinical trials of COVID-19 vaccine 'catastrophic,' says editorial

http://global.chinadaily.com.cn/a/202005/23/WS5ec88c5ca310a8b241157ca4.html

Bypassing clinical trials of a potential vaccine for #SARS-CoV-2, the virus causing #COVID-19, would be "catastrophic," said an editorial published on #Science Advances on Friday.

It is "vital to take time" to ensure any vaccine candidate's safety and investigate potential adverse effects, said the editorial by Douglas Green, deputy editor of the multidisciplinary scientific journal.

A vaccine able to trigger strong neutralizing antibody responses in #clinical tests will still not be ready for widespread implementation without comprehensive safety tests, wrote Green, who is also an expert on #immunology.

Vaccines must be examined for causing an effect known as antibody-dependent enhancement, whereby #vaccine-induced #antibodies that bind to the #virus also attach to the body's #cells, facilitating #infection of these cells -- a concerning phenomenon that has been observed in vaccines against #dengue, #Ebola, #HIV, and #feline #coronavirus, said the editorial.

Ethical accelerated testing on humans "should not be ruled out completely," but extreme risks must be weighed against potential benefits, it said.

There are currently 95 vaccines under development against SARS-CoV-2, with most expected to clear phase one, and two already moving into phase two trials, it added.
 

A choir decided to go ahead with rehearsal. Now dozens of members have COVID-19 and two are dead | LA Times

the choir outbreak is consistent with a growing body of evidence that the virus can be transmitted through aerosols — particles smaller than 5 micrometers that can float in the air for minutes or longer.

...a study published March 17 in the New England Journal of Medicine found that when the virus was suspended in a mist under laboratory conditions it remained “viable and infectious” for three hours — though researchers have said that time period would probably be no more than a half-hour in real-world conditions.

...it’s possible that the forceful breathing action of singing dispersed viral particles in the church room that were widely inhaled.

...some people happen to be especially good at exhaling fine material, producing 1,000 times more than others.

Amateur singers interested in choral music tend to be older, but the group includes some young adults.

...The youngest of those sickened was 31, but they averaged 67
https://www.latimes.com/world-nation/story/2020-03-29/coronavirus-choir-outbreak

#covid-19 #covid19 #covid 19 #coronavirus #SARS-CoV-2 #SocialDistancing #aerosols #distancing
 

A choir decided to go ahead with rehearsal. Now dozens of members have COVID-19 and two are dead | LA Times

the choir outbreak is consistent with a growing body of evidence that the virus can be transmitted through aerosols — particles smaller than 5 micrometers that can float in the air for minutes or longer.

...a study published March 17 in the New England Journal of Medicine found that when the virus was suspended in a mist under laboratory conditions it remained “viable and infectious” for three hours — though researchers have said that time period would probably be no more than a half-hour in real-world conditions.

...it’s possible that the forceful breathing action of singing dispersed viral particles in the church room that were widely inhaled.

...some people happen to be especially good at exhaling fine material, producing 1,000 times more than others.

Amateur singers interested in choral music tend to be older, but the group includes some young adults.

...The youngest of those sickened was 31, but they averaged 67
https://www.latimes.com/world-nation/story/2020-03-29/coronavirus-choir-outbreak

#covid-19 #covid19 #covid 19 #coronavirus #SARS-CoV-2 #SocialDistancing #aerosols #distancing
 
SoftBank behavior is worse than callous, it's criminally insane!
#patent #troll #SoftBank #Theranos #COVID-19 #SARS-CoV-2 #coronavirus

SoftBank Owned Patent Troll, Using Monkey Selfie Law Firm, Sues To Block Covid-19 Testing, Using Theranos Patents | Techdirt

However, back in 2018, the remains of Theranos sold its patents to Fortress Investment Group. Fortress Investment Group is a SoftBank-funded massive patent troll. You may remember the name from the time last fall when Apple and Intel sued the firm, laying out how Fortress is a sort of uber-patent troll, gathering up a bunch of patents and then shaking down basically everyone. Lovely, right?

So, this SoftBank-owned patent troll, Fortress, bought up Theranos patents, and then set up this shell company, "Labrador Diagnostics," which decided that right in the midst of the Covid-19 pandemic it was going to sue one of the companies making Covid-19 tests, saying that its test violates those Theranos patents, and literally demanding that the court bar the firm from making those Covid-19 tests.
 
SoftBank behavior is worse than callous, it's criminally insane!
#patent #troll #SoftBank #Theranos #COVID-19 #SARS-CoV-2 #coronavirus

SoftBank Owned Patent Troll, Using Monkey Selfie Law Firm, Sues To Block Covid-19 Testing, Using Theranos Patents | Techdirt

However, back in 2018, the remains of Theranos sold its patents to Fortress Investment Group. Fortress Investment Group is a SoftBank-funded massive patent troll. You may remember the name from the time last fall when Apple and Intel sued the firm, laying out how Fortress is a sort of uber-patent troll, gathering up a bunch of patents and then shaking down basically everyone. Lovely, right?

So, this SoftBank-owned patent troll, Fortress, bought up Theranos patents, and then set up this shell company, "Labrador Diagnostics," which decided that right in the midst of the Covid-19 pandemic it was going to sue one of the companies making Covid-19 tests, saying that its test violates those Theranos patents, and literally demanding that the court bar the firm from making those Covid-19 tests.
 
Das #Coronavirus-Update mit Christian #Drosten #NDR
#Sars-CoV-2, das neue #Coronavirus, hat sich zuerst in #China ausgebreitet und ist nun Tag für Tag in den Schlagzeilen. Doch wie können wir so viele Menschen wie möglich so fundiert wie möglich informieren - ohne dabei unnötige Panik zu verbreiten? NDR Info Wissenschaftsredakteurin Korinna Hennig spricht jeden Tag mit einem der führenden Virus-Forscher Deutschlands: Christian Drosten, dem Leiter der Virologie in der Berliner #Charité.

Welche Spur verfolgt die Forschung aktuell? Welche neuen Erkenntnisse gibt es zu Ansteckung und Krankheitsverlauf? Ist die Aufregung um das neue Virus überhaupt angemessen? Und: Wie ergeht es den Forschern persönlich in diesen Tagen?

https://www.ndr.de/nachrichten/info/podcast4684.html

das lohnt sich jeden Tag aufs Neue.
 
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